The Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition (HI-SPEED) study is a National Institute of Neurological Disorders and Stroke (NINDS)-funded, stepped wedge, cluster randomized trial involving eight health systems across the United States. The HI-SPEED study seeks to implement a seven-component intervention to improve the accuracy and timeliness of acute stroke diagnosis and door-in-door-out time for patients requiring transfer from a non-Comprehensive Stroke Center [i.e., acute stroke ready hospital (ASRH) or Primary Stroke Center(PSC)] to a Comprehensive Stroke Center for patients seeking care in the Emergency Department. This study is being led by the University of Chicago.

Please visit https://hispeedstudy.bsd.uchicago.edu/ to learn more!

AIM 1: Prepare, implement, and evaluate the HI-SPEED protocol in a multicenter, prospective cluster-randomized, controlled study to reduce (a) median DIDO time for AIS (10 outcome); (b) median DIDO time for HS (20 outcome); and (c) 3-month disability after EVT for AIS (20 outcome).

AIM 2: Evaluate HI-SPEED implementation and contextual adaptations of HI-SPEED by (a) assessing quantitative and qualitative measures of HI-SPEED adoption, fidelity, and sustainability; and (b) identifying predictors of high-quality (>80% of each component) implementation.

Learning Collaborative Sessions, Implementation Preparation Team, Use of Multi-Site Collaboration Portal, Performance Data Reports, Preparation and Sustainment Phase Semi-Structured Interviews, use of American Heart Association Get-With-The-Guidelines Stroke registry data for for patient data collection