The mission of our lab is to fill the gap between clinical practice and basic science through translational research. Our key research area is cardiovascular tissue engineering using 3D printing/ bioprinting technology. Please see http://hibinolab.com/.

First, we aim to use innovative and novel tissue engineering approaches to regenerate the heart using 3D cardiac engineered tissues. The second focus of our lab is patient-specific vascular tissue engineering using 3D printing technology. Our ultimate goal is to create a new history to apply these basic researches into clinical fields to improve patient's quality of life.

First focus is to 3D bioprint cardiac patches without biomaterials, and characterize them using a variety of techniques, such as histology, immunohistochemistry, electrophysiology, biomechanics. Another focus of the Hibino lab is tissue-engineered vascular graft (TEVG) research. TEVGs offer the potential to overcome thrombogenicity, immune responses causing functional deterioration, and lack of growth potential by providing a biodegradable scaffold on which a patient's own cells can proliferate and provide physiologic functionality. We investigate the conditions necessary to create the ideal TEVG, using a combination of cutting edge fabrication tools and polymers/biomaterials, as well as the mechanism of neotissue formation. Recently, by combining axial imaging technology, computer-aided design, computational flow dynamics and artificial intelligence, with advanced 3D printing and biomaterials, we have created preoperatively designed, patient-specific TEVGs, that have the potential to improve surgical outcomes.