We have developed a retrospective cohort database of patients who have received ECMO as part of their care at the University of Chicago and this project seeks to investigate the prevalence, impact and outcome of patients kidney injury in the setting of ECMO. This is little known published data on the short and long term outcomes of AKI in the setting of ECMO, with even less known about the impact of those patients requiring dialysis for severe AKI. This project seeks to further our understanding of AKI and RRT in the setting of ECMO.

1) To assess the incidence of AKI, according to KDIGO consensus definitions of AKI in patients receiving ECMO.

2) To determine the length of stay, duration of mechanical ventilation, inpatient mortality is different in patients with AKI undergoing ECMO both with and without RRT??

3) Are outcomes different in those receiving RRT with ECMO different depending on the modality or manner in which CRRT is set up? (Filter life, duration of RRT, renal recovery, length of stay, mortality)?

4) Are filter lives and patient outcomes (mortality, length of stay) different in patients with pre-existing ESRD requiring ECMO compared to those with AKI requiring ECMO?

5) Are patient outcomes (mortality, length of stay) different in patients with RRT requiring AKI prior to the start of ECMO compared to those who develop RRT requiring AKI after being placed on ECMO?

Data will be extracted from the EMR (EPIC) - This is a retrospective cohort study that will use standard statistical methods including

1) Student's t-test and Mann Whitney Rank Sum test for parametric and non-parametric data

2) Chi-squared for categorical variables and proportion of death in each group

3) Logistic regression will be used to look at factors that predict mortality in patients to determine if AKI is an independent risk factor for mortality in patients on ECMO

4) We will perform Kaplan-Meier survival analyses to determine if there are differences in mortality over time in those with and without AKI.

Microsoft Excel, Stata and Sigma Plot - all of which will be provided by the mentor

All of the Nephrology summer conferences, Dr. Koyner's Thursday pm clinic where he cares for AKI follow up patients.